CoREST (RCOR1) Mouse Monoclonal Antibody [Clone ID: S72-8]

CAT#: TA326451

Mouse Monoclonal Anti-Co-Rest/RCOR1 Antibody

Product Images

IHC analysis of C-Rest/ RCOR1 using the antibody

Specifications

Product Data

• Clone Name: S72-8
• Applications: IHC
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, ICC: 0.1-1ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 109-293 of human Co-Rest
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: REST corepressor 1
• Database Link:
  NP_055971
  Entrez Gene 217864 MouseEntrez Gene 102554884 RatEntrez Gene 23186 Human
  UniProt ID Q9UKL0
• Background: The RCOR1 gene encodes a functional corepressor required for regulation of neural-specific gene expression . Co-Rest (corepressor for element-1-silencing transcription factor) is the primary cofactor of Rest, and recruits additional epigenetic factors similarily associated with gene activation and repression . Co-rest has been found to be an essential component of the repression mechanism used to block expression of type II sodium channel reporter genes in non-neuronal cell types . It has also been demonstrated that the corepressor function of Co-REST depends on an HDAC1/2-interacting region containing a SANT domain .
• Synonyms: COREST; RCOR
• Note: Detects ~66-80kDa (Depending on gel system used)

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Huntington's disease