Aqp2 Rabbit Polyclonal Antibody

CAT#: TA326511

Rabbit Polyclonal Anti-Aquaporin 2 Antibody

Product Images

Western blot analysis of Aquaporin 2 in rat kidney tissue using a 1 in 2000 dilution of the antibody

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  IF analysis of Aquaporin 2 in rat kidney tissues using a 1 in 200 dilution of the antibody

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB 1:1000-4000, IF: 1:400
• Reactivities: Human, Mouse, Rat. Not yet tested on other species
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal peptide
• Formulation: PBS pH7.4, 50% glycerol and 0.09% sodium azide
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: aquaporin 2
• Database Link:
  NP_037041
  Entrez Gene 359 HumanEntrez Gene 11827 MouseEntrez Gene 25386 Rat
  UniProt ID P34080
• Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins .Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell . Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) .
• Synonyms: AQP-2; AQP-CD; aquaporin-CD; MGC34501; WCH-CD
• Note: Detects ~28.8kDa. May detect larger glycosylated bands ~35-50kDa.