Grin1 Mouse Monoclonal Antibody [Clone ID: S308-48]

CAT#: TA326536

Mouse Monoclonal Anti-GluN1-NR1 Antibody

Product Images

Western blot analysis of GluN1-NR1 in rat brain membrane tissues, using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: S308-48
• Applications: WB
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
• Formulation: PBS pH7.4, 50% glycerol
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: glutamate ionotropic receptor NMDA type subunit 1
• Database Link:
  NP_058706
  Entrez Gene 2902 HumanEntrez Gene 14810 MouseEntrez Gene 24408 Rat
  UniProt ID P35439
• Background: The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controllingsynaptic plasticity and memory function . The NMDA receptor forms a heterotetramer between two NR1 andtwo NR2 subunits (the subunits are also called glutamatebinding NMDA receptor subunits or GluN for short); twoobligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunitshave an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions andfunctional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2subunits.
• Synonyms: NMDA1; NMDAR1; NR1
• Note: Detects ~105kDa.