Slc12a1 Rabbit Polyclonal Antibody

CAT#: TA326586

Rabbit Polyclonal Anti-NKCC2 Antibody

Product Images

Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of the antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: AA109 to 129 of the rat sequence
• Formulation: PBS, 50% glycerol and 0.09% sodium azide
• Concentration: lot specific
• Purification: Affinity Purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: solute carrier family 12 member 1
• Database Link:
  NP_062007
  Entrez Gene 6557 HumanEntrez Gene 20495 MouseEntrez Gene 25065 Rat
• Background: NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell . Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide .
• Synonyms: BSC1; MGC48843; NKCC2
• Note: Detects ~160kDa.