ERAP2 Rabbit Polyclonal Antibody

CAT#: TA326651

Rabbit Polyclonal ERAP2 Antibody

Product Images

Western blot analysis of ERAP2 in rat small intestine tissue lysate with ERAP2 antibody at 1 ug/ml.

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  Immunohistochemistry of ERAP2 in rat small intestine tissue with ERAP2 antibody at 5 ug/mL.

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  Immunofluorescence of ERAP2 in rat small intestine tissue with ERAP2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2.
• Formulation: ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: ERAP2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 106 kDa; Observed: 103 kDa
• Gene Name: endoplasmic reticulum aminopeptidase 2
• Database Link:
  NP_071745
  Entrez Gene 64167 Human
  UniProt ID Q6P179
• Background: The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1). Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3).
• Synonyms: L-RAP; LRAP

Reference Data

• Protein Families: Druggable Genome, Protease