ULK3 Rabbit Polyclonal Antibody
Other products for "ULK3"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | ULK3 antibody was raised against a 19 amino acid peptide near the center of human ULK3. |
Formulation | ULK3 antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | ULK3 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | Predicted: 52 kDa; Observed: 52 kDa |
Gene Name | unc-51 like kinase 3 |
Database Link | |
Background | ULK3 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1). Knockout of ULK genes results in a severe defect in the autophagy pathway (2). ULK3, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK4, is highly conserved among eukaryotes (3). ULK3 has been shown to be a positive regulator of the Hedgehog signaling pathway by enhancing GLI1 and GLI2 transcriptional activity (4). Furthermore, ULK3 can also interact with SUFU, a protein required for the negative regulation of GLI proteins; this interaction blocks the autophosphorylation of ULK3 and blocks its ability to regulate the GLI proteins (5). |
Synonyms | DKFZp434C131; FLJ90566 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | mTOR signaling pathway, Regulation of autophagy |
Documents
Product Manuals |
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