PHC3 Rabbit Polyclonal Antibody

CAT#: TA326692

Rabbit Polyclonal PHC3 Antibody

Product Images

Western blot analysis of PHC3 in 3T3 cell lysate with PHC3 antibody at (A) 1 and (B) 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3.
• Formulation: PHC3 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PHC3 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 109 kDa; Observed: 120 kDa
• Gene Name: polyhomeotic homolog 3
• Database Link:
  NP_079223
  Entrez Gene 241915 MouseEntrez Gene 310258 RatEntrez Gene 80012 Human
  UniProt ID Q8NDX5
• Background: Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2). PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3). PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).
• Synonyms: EDR3; HPH3