GRK6 Rabbit Polyclonal Antibody

CAT#: TA326701

Rabbit Polyclonal GRK6 Antibody

Product Images

Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 ug/ml.

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  Immunohistochemistry of GRK6 in human small intestine tissue with GRK6 antibody at 5 ug/mL.

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  Immunofluorescence of GRK6 in human small intestine tissue with GRK6 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6.
• Formulation: GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: GRK6 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 63 kDa; Observed: 63 kDa
• Gene Name: G protein-coupled receptor kinase 6
• Database Link:
  NP_002073
  Entrez Gene 26385 MouseEntrez Gene 59076 RatEntrez Gene 2870 Human
  UniProt ID P43250
• Background: The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).
• Synonyms: GPRK6

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Endocytosis