SPHK1 Rabbit Polyclonal Antibody

CAT#: TA326762

SPHK1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using SPHK1 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human SPHK1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sphingosine kinase 1
• Database Link:
  NP_068807
  Entrez Gene 20698 MouseEntrez Gene 170897 RatEntrez Gene 8877 Human
  UniProt ID Q9NYA1
• Background: Sphingosine kinases (SPHKs) catalyze the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Together with other sphingolipid metobolizing enzymes, SPHKs regulate the balance of the lipid mediators, ceramide, sphingosine, and S1P. Two distinct SPHK isoforms, SPHK1 and SPHK2, have been cloned and characterized. SPHK1 and SPHK2 are highly conserved and diverselly expressed. The SPHKs are activated by G-protein-coupled receptors, receptor tyrosine kinases, immunoglobulin receptors, cytokines, and other stimuli . The molecular mechanisms by which SPHK1 and SPHK2 are specifically regulated are complex and only partially understood.
• Synonyms: SPHK

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Metabolic pathways, Sphingolipid metabolism, VEGF signaling pathway