GDF15 Rabbit Polyclonal Antibody

CAT#: TA326764

Rabbit anti-GDF15 Polyclonal Antibody

Product Images

Western blot analysis of SW620 cell lysate using GDF15 antibody.

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  Immunohistochemistry of paraffin-embedded human lung cancer using GDF15 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat kidney using GDF15 antibody at dilution of 1:200 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat lung using GDF15 antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, IP, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200
• Reactivities: Human, Rat, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human GDF15
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: growth differentiation factor 15
• Database Link:
  NP_004855
  Entrez Gene 23886 MouseEntrez Gene 29455 RatEntrez Gene 9518 Human
  UniProt ID Q99988
• Background: Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15, PTGF-β, PLAB, PDF, and NAG-1, is a divergent member of the transforming growth factor-β (TGF-β) superfamily. Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid. It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity. During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer.
• Synonyms: GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB

Reference Data

• Protein Families: Druggable Genome, Secreted Protein