MLH1 Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
USD 823.00
Transient overexpression lysate of mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 1
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Other products for "MLH1"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | WB 1:500 - 1:2000 |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human MLH1 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 85 kDa |
Gene Name | mutL homolog 1 |
Database Link | |
Background | Mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. MLH1 is the human homologue of the E. coli MMR gene mutL. MMR requires recognition of a base mismatch or insertion/deletion loop by a MutS homolog followed by recruitment of a MutL heterodimeric complex consisting of MLH1 and PMS1 ((MutL-a), PMS2 (MutL-β) or MLH3 (MutL-?). Other factors required for MMR in eukaryotes are EXO1, PCNA, RFC, RPA, DNA polymerases and DNA ligase (reviewed in 1). Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. The MLH1 gene is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). MLH1 also plays a role in meiotic recombination . |
Synonyms | COCA2; FCC2; hMLH1; HNPCC; HNPCC2 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer |
Documents
Product Manuals |
FAQs |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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