Caspase-7 (CASP7) Rabbit Polyclonal Antibody

CAT#: TA327065

CASP7 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using CASP7 antibody.

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  Immunohistochemistry of paraffin-embedded rat heart using Casp7 antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded human lung cancer using Casp7 antibody at dilution of 1:100 (400x lens).

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  Immunohistochemistry of paraffin-embedded rat heart using Casp7 antibody at dilution of 1:100 (400x lens).

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human CASP7
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 34 kDa
• Gene Name: caspase 7
• Database Link:
  NP_001218
  Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 840 Human
  UniProt ID P55210
• Background: Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis . Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP . During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits . Similar to caspases-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD .
• Synonyms: CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Alzheimer's disease, Apoptosis