TCPTP (PTPN2) Rabbit Polyclonal Antibody

CAT#: TA327184

PTPN2 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PTPN2 antibody.

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  Immunofluorescence analysis of MCF7 cell using PTPN2 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human PTPN2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein tyrosine phosphatase, non-receptor type 2
• Database Link:
  NP_002819
  Entrez Gene 19255 MouseEntrez Gene 117063 RatEntrez Gene 5771 Human
  UniProt ID P17706
• Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
• Synonyms: PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane