PCK1 Rabbit Polyclonal Antibody

CAT#: TA327236

PCK1 Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using PCK1 antibody.

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  Immunohistochemical of paraffin-embedded human endometrial cancer using PCK1 antibody at dilution of 1:200 (200x lens).

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  Immunohistochemical of paraffin-embedded human thyroid cancer using PCK1 antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat testis using PCK1 antibody at dilution of 1:200 (200x lens).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000, IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human PCK1
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: phosphoenolpyruvate carboxykinase 1
• Database Link:
  NP_002582
  Entrez Gene 18534 MouseEntrez Gene 362282 RatEntrez Gene 5105 Human
  UniProt ID P35558
• Background: PCK1(Phosphoenolpyruvate carboxykinase, cytosolic) is also named as PEPCK1 and belongs to the phosphoenolpyruvate carboxykinase [GTP] family. It catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. It is also a main control point for the regulation of gluconeogenesis. In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (C-PEPCKD). This antibody is specific to PCK1.
• Synonyms: PEPCK-C; PEPCK1; PEPCKC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, PPAR signaling pathway, Pyruvate metabolism