MITF Mouse Monoclonal Antibody [Clone ID: C5/D5]

CAT#: TA327700

Mouse Monoclonal MiTF Antibody

Product Images

Immunohistochemistry staining of Paraffin Melanoma tissue by MiTF antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear)

Specifications

Product Data

• Clone Name: C5/D5
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: melanogenesis associated transcription factor
• Database Link:
  NP_000239
  Entrez Gene 4286 Human
  UniProt ID O75030
• Synonyms: bHLHe32; CMM8; MI; WS2; WS2A
• Note: Microphthalmia (MiTF) is a transcription factor implicated in pigmentation, bone development, and in mast cells. Various forms of MiTF exist ranging from 50 -70 kD in size. This antibody targets the 52 - 56 kD range and has been useful in identifying malignant melanoma and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Melanogenesis, Melanoma, Pathways in cancer