NAPSIN A (NAPSA) Mouse Monoclonal Antibody [Clone ID: MRQ-60]

CAT#: TA327712

Mouse Monoclonal Napsin A Antibody

Product Images

Immunohistochemistry staining of Paraffin Lung adenocarcinoma, renal cell carcinoma tissue by Napsin A antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic)

Specifications

Product Data

• Clone Name: MRQ-60
• Applications: IHC
• Recommended Dilution: IHC: 1:100 - 1:500
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: The antibody is diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <1% sodium azide.
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: napsin A aspartic peptidase
• Database Link:
  NP_004842
  Entrez Gene 9476 Human
  UniProt ID O96009
• Synonyms: KAP; Kdap; NAP1; NAPA; SNAPA
• Note: Napsin A is a functional aspartic proteinase that is expressed in the normal lung parenchyma in type II pneumocytes and the proximal and convoluted tubules of the kidney. It is present in the lysosomes of type II pneumocytes and alveolar macrophages (probably secondary to phagocytosis) and to a lesser degree in pancreatic acini and ducts. It is expressed in the cytoplasm and is strongly positive in up to 80% of primary lung adenocarcinomas. Squamous cell carcinomas and small cell carcinomas of the lung are characteristically negative for napsin A. Adenocarcinomas including those from the breast, pancreas, biliary tract, and colon rarely stain with anti-napsin A. Pulmonary adenocarcinoma with enteric differentiation (PAED) is a special case in that essentially none of these cases are labeled by napsin A antibody.

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome