CTIP2 (BCL11B) Rat Monoclonal Antibody [Clone ID: 25B6]

CAT#: TA328046

Rat Monoclonal anti-Bcl11b Antibody

Product Images

Jurkat cell extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-CTIP2 antibody (clone 25B6). Proteins were visualized using a goat anti-rat-IgG secodary conjugated to HRP and chemiluminescence detection.

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  Jurkat cells were stained with anti-bcl11b, clone 25B6 (1:200 dilution), and tubulin-α, clone TU-01, followed by DyLight™ 549 conjugated anti-rat IgG and DyLight™ 488 conjugated anti-mouse IgG. Nuclei are stained with DAPI.

Specifications

Product Data

• Clone Name: 25B6
• Applications: IF, WB
• Recommended Dilution: WB, IF, CHIP, IHC
• Reactivities: Human, Mouse, Zebrafish
• Host: Rat
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Human Bcl11b
• Formulation: This antibody is provided in Hepes-buffered solution, pH 7.5, 0.02% NaN₃.
• Purification: Protein G affinity purified.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 96 kD
• Gene Name: B-cell CLL/lymphoma 11B
• Database Link:
  NP_612808
  Entrez Gene 58208 MouseEntrez Gene 64919 Human
  UniProt ID Q9C0K0
• Background: The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
• Synonyms: ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; RIT1; ZNF856B

Reference Data

• Protein Families: Druggable Genome