HDAC2 Mouse Monoclonal Antibody [Clone ID: 1194CT18.5.1]
Other products for "HDAC2"
Specifications
Product Data | |
Clone Name | 1194CT18.5.1 |
Applications | WB |
Recommended Dilution | WB: 1:1000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | This HDAC2 antibody is generated from a mouse immunized with a recombinant protein between 202-488 amino acids from the Central region of human HDAC2. |
Formulation | PBS with 0.09% (W/V) sodium azide |
Concentration | lot specific |
Purification | This antibody is purified through a protein G column, followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | histone deacetylase 2 |
Database Link | |
Background | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. |
Synonyms | HD2; RPD3; YAF1 |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways | Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer |
Documents
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