GABA A Receptor alpha 3 (GABRA3) Rabbit Polyclonal Antibody
Other products for "GABRA3"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide QGESRRQEPGDFVKQ(C), corresponding to amino acid residues 29-43 of human GABA (A) a3 Receptor. Extracellular, N-terminus. |
Formulation | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
Purification | Affinity purified on immobilized antigen. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | gamma-aminobutyric acid type A receptor alpha3 subunit |
Database Link | |
Background | The neurotransmitter GABA (?-aminobutiric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl channel, producing an increase in membrane conductance that results in inhibition of neural activity. There are two major types of GABA receptors: the ionotropic GABAA receptors (GABAAR) and the metabotropic GABAB receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABAARs are heteropentamers, in which all five subunits contribute to formation of the pore. Eight subunit isoforms have been cloned: a, Ã?, ?, d, e, p, ?, and ?.Six a subunits isoforms (a1-a6) have been shown to exist in mammals. In most cases, the native GABAA receptors consist of 2a, 2Ã?, and 1? subunits. The a3-subunit is highly expressed during development (along with a2 and a5) and then declines in adulthood, where the a1-subunit becomes predominant. The failure to complete this switch could be a major predispositional factor in the development of temporal lobe epilepsy. |
Synonyms | MGC33793 |
Note | This antibody was tested in live cell imaging. Please see IF/ICC data for detail. |
Reference Data | |
Protein Families | Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane |
Protein Pathways | Neuroactive ligand-receptor interaction |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.