Kcnmb1 Rabbit Polyclonal Antibody

CAT#: TA328943

Rabbit polyclonal Anti-slobeta1 (KCNMB1)

Product Images

Western blot analysis of rat smooth muscle lysate: 1. Anti-sloβ1 (KCNMB1) antibody, (1:200). 2. Anti-sloβ1 (KCNMB1) antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide KKLVMAQKRGETRALC, corresponding to amino acid residues 2-17 of rat sloÃ?1. Intracellular, N-terminal part.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily M regulatory beta subunit 1
• Database Link:
  NP_062146
  Entrez Gene 3779 HumanEntrez Gene 16533 MouseEntrez Gene 29747 Rat
  UniProt ID P97678
• Background: sloÃ?1 is a member of a family of regulatory Ã? subunits that control the activity of the large conductance Ca2+-activated K+ channel KCa1.1. The family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region. The four members of the family have a distinct tissue distribution with sloÃ?1 expressed almost exclusively in smooth muscle. Functionally, sloÃ?1 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. In the past few years there has been a lot interest regarding the role of the sloÃ?1 subunit in the regulation of vascular tone and hypertension. Studies in sloÃ?1 knockout mice have shown that loss of this subunit results in systemic hypertension. Conversely, a recent study showed that a commonly found gain-of-function sloÃ?1 variant has a protective effect against human diastolic hypertension.
• Synonyms: BKbeta; BKbeta1; Hbeta1; hslo-beta; K(VCA)beta; K(VCA)beta-1; Slo-beta; Slo-beta-1