Kcnq5 Rabbit Polyclonal Antibody

CAT#: TA328990

Rabbit polyclonal Anti-KV7.5

Product Images

Western blot analysis of rat hippocampus lysate (lanes 1 and 4), mouse brain lysate (lanes 2 and 5) an rat brain lysate (lanes 3 and 6): 1-3. Anti-Kv7.5 antibody, (1:200). 4-5. Anti-Kv7.5 antibody, preincubated with the control peptide antigen.

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  Expression of Kv7.5 in rat hippocampus. Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Kv7.5 antibody, (1:100). A. Kv7.5 (green) is expressed in hilar cells of the hippocampal dentate gyrus. B. Double-staining of Kv7.5 (green) with a neuronal marker (“Milli-Mark” from Millipore, red) reveals partial localization with hilar interneurons (arrow points at an example).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:200-1:2000; IHC: 1:100-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)RGSQDFYPKWRESK, corresponding to amino acid residues 856-869 of mouse Kv7.5 . Intracellular, C-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium voltage-gated channel, subfamily Q, member 5
• Database Link:
  NP_076361
  Entrez Gene 56479 HumanEntrez Gene 259273 RatEntrez Gene 226922 Mouse
  UniProt ID Q9JK45
• Background: KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KV7.1-KV7.5) of which KV7.2 to KV7.5 are expressed in the nervous system1-3. KV7.5 is also expressed in visceral smooth muscle4 and skeletal muscle. These channels form subunits of the low threshold voltage gated K+ channel. KV7.2 and KV7.3 mostly form heteromers to form the M current. KV7.5 is known to contribute to this current.
• Synonyms: Kv7.5