TRADD Rabbit Polyclonal Antibody

CAT#: TA330326

Rabbit Polyclonal Anti-TRADD Antibody

Product Images

WB Suggested Anti-TRADD Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: DU145 cell lysateThere is BioGPS gene expression data showing that TRADD is expressed in DU145

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  Lanes: Lane 1: 10ug Tradd-HA-Strep-stable expression 293T REXFlpIn cells-Doxycycline induced; Lane 2: 10 ug ITradd-HA-Strep-stable expression 293T REXFlpIn cells-non-induced; Lane 3: 10 ug siRNA scrambled-MDA-MB-231 cells; Lane 4: siRNA Tradd-MDA-MB-231 c

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TRADD antibody: synthetic peptide directed towards the middle region of human TRADD. Synthetic peptide located within the following region: YEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGL
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 34 kDa
• Gene Name: TNFRSF1A associated via death domain
• Database Link:
  NP_003780
  Entrez Gene 8717 Human
  UniProt ID Q15628
• Background: TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Synonyms: Hs.89862
• Note: Immunogen sequence homology: Human: 100%; Dog: 76%; Horse: 76%

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway