ING3 Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of inhibitor of growth family, member 3 (ING3), transcript variant 1
USD 605.00
Other products for "ING3"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB 1:500 - 1:2000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human ING3 |
Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | inhibitor of growth family member 3 |
Database Link | |
Background | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. |
Synonyms | Eaf4; ING2; MEAF4; p47ING3 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Documents
Product Manuals |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.