Cofilin 1 (CFL1) Rabbit Polyclonal Antibody

CAT#: TA333182

Phospho-CFL1-Y139 Rabbit Polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Phospho-CFL1-Y139 antibody.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC 1:50-1:100
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y139 of human CFL1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 166
• Gene Name: cofilin 1
• Database Link:
  NP_005498
  Entrez Gene 12631 MouseEntrez Gene 29271 RatEntrez Gene 1072 Human
  UniProt ID P23528
• Background: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
• Synonyms: CFL; HEL-S-15

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton