MSI1 Rabbit Polyclonal Antibody

CAT#: TA336268

Rabbit Polyclonal Musashi-1 Antibody

Product Images

Western Blot: Musashi 1 Antibody TA336268 - WB detection of Musashi-1 protein in 10 ug of rat neural stem cell lysate (lane 1) and normal human brain lysate (lane 2) with Musashi-1 antibody TA336268 at a dilution of 1:500.

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  Immunocytochemistry/Immunofluorescence: Musashi 1 Antibody TA336268 - Image of staining with Musashi polyclonal antibody (1:100 dilution) shows Musashi (green) staining on neural rosettes (human). Nuclei are counterstained blue (DAPI). Cells were fixed

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  Immunocytochemistry/Immunofluorescence: Musashi 1 Antibody TA336268 - Musashi-positive cells stained with Musashi antibody (1:150 dilution) in the ventricular zone of E14.5 mouse medulla. Image taken at 200x magnification. The sections were 4% PFA f

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1:500, IHC: 1:10-1:500, IHC-P: 1:10-1:500
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Reacts with residues 5-21 [APQPGLASPDSPHDPCK] of the human, mouse and rat Musashi 1 protein.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: musashi RNA binding protein 1
• Database Link:
  NP_002433
  Entrez Gene 17690 MouseEntrez Gene 259272 RatEntrez Gene 4440 Human
  UniProt ID O43347
• Background: Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia. It may play a role in the pathogenesis of various neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.
• Synonyms: musashi 1; musashi homolog 1 (Drosophila)
• Note: Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 24006477)