SIRT5 Rabbit Polyclonal Antibody

CAT#: TA336344

Rabbit Polyclonal Sirtuin 5/SIRT5 Antibody

Product Images

Western Blot: Sirtuin 5/SIRT5 Antibody TA336344 - Analysis of Sirtuin 5/SIRT5 in A) human, B) mouse and C) rat intestine cell lysate using this antibody at 2 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1-3 ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to amino acids 30-46 of human SIRT5 was used as immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sirtuin 5
• Database Link:
  NP_112534
  Entrez Gene 68346 MouseEntrez Gene 306840 RatEntrez Gene 23408 Human
  UniProt ID Q9NXA8
• Background: SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
• Synonyms: SIR2L5

Reference Data

• Protein Families: Druggable Genome, Transcription Factors