Caspase-7 (CASP7) Mouse Monoclonal Antibody [Clone ID: 25B881.1]
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Other products for "Caspase-7"
Specifications
Product Data | |
Clone Name | 25B881.1 |
Applications | IHC, WB |
Recommended Dilution | Immunohistochemistry, Western Blot: 1-2 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | This antibody was generated against recombinant protein of active form of human Caspase-7. |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | caspase 7 |
Database Link | |
Background | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-7 is derived from the cleavage of proMCH3-alpha into 2 subunits, p20 and p12 by Caspase-3. Sequence analysis revealed that the MCH3-alpha amino acid sequence had the highest homology to caspase-3 (53% identity) and less than 37% identity with all other family members. |
Synonyms | CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3 |
Reference Data | |
Protein Families | Druggable Genome, Protease |
Protein Pathways | Alzheimer's disease, Apoptosis |
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