Metabotropic Glutamate Receptor 1 (GRM1) Rabbit Polyclonal Antibody

CAT#: TA336498

Rabbit Polyclonal metabotropic Glutamate Receptor 1a Antibody

Product Images

Western Blot: metabotropic Glutamate Receptor 1a Antibody TA336498 - Detection of metabotropic Glutamate Receptor 1a protein in 20ug of human brain lysate (lane 2) with the use of TA336498 as a primary antibody at 1:1000 dilution and an AP conjugated s

• 

  Immunohistochemistry: metabotropic Glutamate Receptor 1a Antibody TA336498 - Recommended dilution for IHC is 1:100-500. However, the investigator should determine the optimal dilution for a specific application.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:500-1:1000, IHC: 1:100-1:500, IHC-F:
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide comprising internal residues of the human GluR1 alpha protein. Reacts with rat and mouse GluR1.
• Formulation: PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 132.4 kDa
• Gene Name: glutamate metabotropic receptor 1
• Database Link:
  NP_000829
  Entrez Gene 14816 MouseEntrez Gene 24414 RatEntrez Gene 2911 Human
  UniProt ID Q13255
• Background: The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).
• Synonyms: GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13
• Note: This antibody is useful for Western blot 1:500-1:1000, and immunohistochemistry 1:100-1:500. Immunocytochemistry/Immunofluorescence and Immunohistochemistry-Frozen were reported in scientific literature.

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Gap junction, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction