CAMK2B Rat Polyclonal Antibody

CAT#: TA336581

Rat Polyclonal CaMKII beta Antibody

Product Images

Immunocytochemistry/Immunofluorescence: CaMKII beta Antibody TA336581 - Staining of CAMKIIb using TA336581 in rat hippocampal neurons at a dilution of 1:100, note that staining is rather weak.

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  Western Blot: CaMKII beta Antibody TA336581 - Analysis of CAMKIIb in rat brain lysate using TA336581 at 1:2000.

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  Western Blot: CaMKII beta Antibody TA336581 - Analysis of CAMKII beta in A) human, B) mouse and C) rat brain lysate using CAMKII beta antibody at 1:2000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot
• Reactivities: Human, Mouse, Rat
• Host: Rat
• Clonality: Polyclonal
• Immunogen: This antibody was developed against a synthetic peptide corresponding to amino acids 499-513 (VRRGSGTPEAEAPRQ) of human CAMKII beta.
• Formulation: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calcium/calmodulin dependent protein kinase II beta
• Database Link:
  NP_742075
  Entrez Gene 12323 MouseEntrez Gene 24245 RatEntrez Gene 816 Human
  UniProt ID Q13554
• Background: The multifunctional CaMKII beta, or Ca2+/calmodulin-dependent protein kinase II, is a well known effector of calcium- and calmodulin- mediated functions. It is present in many tissues but is most abundant in the brain. CaMKII is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Autophosphorylation plays an important role in the regulation of the kinase activity. CaMKII is required for synaptic plasticity, as in Long Term Potentiation (LTP), a cellular model for learning and memory.
• Synonyms: CAM2; CAMK2; CAMKB

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway