DRP1 (DNM1L) Mouse Monoclonal Antibody [Clone ID: 4E11B11]

CAT#: TA336948

Mouse Monoclonal DRP1 Antibody (4E11B11)

Product Images

Immunohistochemistry: DRP1 Antibody (4E11B11) TA336948 - Analysis of paraffin-embedded human cerebellum tissues using DRP1 mouse mAb with DAB staining.

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  Immunohistochemistry: DRP1 Antibody (4E11B11) TA336948 - Analysis of paraffin-embedded human ovarian cancer tissues using DRP1 mouse mAb with DAB staining.

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  Western Blot: DRP1 Antibody (4E11B11) TA336948 - Analysis using DRP1 mouse mAb in (1) A549 and (2) Jurkat cell lysates.

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  Western Blot: DRP1 Antibody (4E11B11) TA336948 - Analysis using DRP1 mAb in human DRP1 recombinant protein. (Expected MW is 41.8 kDa)

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  Western Blot: DRP1 Antibody (4E11B11) TA336948 - Analysis using DRP1 mAb in (1) HEK293 and (2) DRP1 hIgGFc transfected HEK293 cell lysate.

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Specifications

Product Data

• Clone Name: 4E11B11
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry: 1:200 - 1:1000, Immunohistochemistry-Paraffin: 1:200 - 1:1000, Western Blot: 1:500 - 1:2000, ELISA: 1:10000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Partial recombinant human DRP1 (between residues 100-250) expressed in E. coli. [UniProt O00429]
• Formulation: PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Ammonium sulfate precipitation
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dynamin 1-like
• Database Link:
  NP_036192
  Entrez Gene 10059 Human
  UniProt ID O00429
• Background: A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
• Synonyms: DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV

Reference Data

• Protein Pathways: Endocytosis, Fc gamma R-mediated phagocytosis