CD36 Rabbit Polyclonal Antibody

CAT#: TA337173

Rabbit Polyclonal CD36/SR-B3 Antibody

Product Images

Western Blot: CD36 Antibody TA337173 - Analysis of CD36 in human platelets using this antibody at 1:200.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Human CD36 amino acids 99-124.
• Formulation: PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD36 molecule
• Database Link:
  NP_000063
  Entrez Gene 948 Human
  UniProt ID P16671
• Background: CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells in atherosclerotic lesions. This membrane glycoprotein can internalize fatty acids which activate PPARand stimulate further expression of CD36. This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments, and post-apoptotic monocytes and neutrophils.CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia.This transmembrane glycoprotein is detected by immunoblotting at 88 kDa or 54 kDa depending on the degree of glycosylation of the receptor in your sample.
• Synonyms: BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, ECM-receptor interaction, Hematopoietic cell lineage, PPAR signaling pathway