alpha 2a Adrenergic Receptor (ADRA2A) Rabbit Polyclonal Antibody

CAT#: TA342798

Rabbit Polyclonal Anti-ADRA2A Antibody

Product Images

WB Suggested Anti-ADRA2A Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Thymus

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-ADRA2A antibody is: synthetic peptide directed towards the C-terminal region of Human ADRA2A. Synthetic peptide located within the following region: RRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAK
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 49 kDa
• Gene Name: adrenoceptor alpha 2A
• Database Link:
  NP_000672
  Entrez Gene 150 Human
  UniProt ID P08913
• Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
• Synonyms: ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
• Note: Immunogen Sequence Homology: Human: 100%; Bovine: 92%; Dog: 85%; Pig: 85%; Rat: 79%; Mouse: 79%; Guinea pig: 79%

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction