H2A.Z (H2AFZ) Rabbit Polyclonal Antibody

CAT#: TA347133

Rabbit Polyclonal H2A.Zac Antibody


USD 490.00

5 Days*

Size
    • 50 ug

Frequently bought together (3)
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Specifications

Product Data
Applications Dot, ELISA, IF
Recommended Dilution ChIP/ChIP-seq (1ug per ChIP); ELISA (1:500 ?? 1:200); Dot blotting (1:20,000); Immunofluoresence (1:500)
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-H2A.Zac antibody: histone H2A.Z acetylated at lysines 5, 7 and 11, using a KLH-conjugated synthetic peptide.
Concentration lot specific
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name H2A histone family member Z
Background Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of the histone H2A variant H2A.Z is associated with the promoters of active genes.
Synonyms H2A; H2A.z; H2A.Z-1; H2AZ; z
Reference Data
Protein Families Druggable Genome
Protein Pathways Systemic lupus erythematosus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.