Retinoic Acid Receptor alpha (RARA) Rabbit Polyclonal Antibody
Frequently bought together (2)
Transient overexpression lysate of retinoic acid receptor, alpha (RARA), transcript variant 1
USD 396.00
Other products for "RARA"
Specifications
Product Data | |
Applications | ELISA, WB |
Recommended Dilution | ChIP/ChIP-seq (4 µl/ChIP); ELISA (1:50); Western blotting (1:750) |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | The immunogen for anti-RARA antibody: human RARA (Retinoic Acid Receptor alpha) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein. |
Concentration | lot specific |
Purification | Whole antiserum from rabbit containing 0.05% azide. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | retinoic acid receptor alpha |
Database Link | |
Background | RARA (UniProtKB/Swiss-Prot entry P10276) is a receptor for retinoic acid, a vitamin A metabolite, which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand, this receptor represses transcription through the recruitment of specific corepressors and of HDAC's, whereas binding of retinioc acid causes the recruitment of coactivators and HAT's. Translocations involving the RARA gene, often leading to a RARA/PML fusion protein, are a major cause of acute promyelocytic leukemia. |
Synonyms | NR1B1; RAR |
Reference Data | |
Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
Protein Pathways | Acute myeloid leukemia, Pathways in cancer |
Documents
Product Manuals |
FAQs |
SDS |
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