Claudin 1 (CLDN1) Rabbit Polyclonal Antibody

CAT#: TA347351

Rabbit Polyclonal Anti-Claudin 1 Antibody

Product Images

Western blot analysis on HeLa cell lysate using Claudin 1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Claudin 1 Antibody: A synthesized peptide derived from human Claudin 1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: claudin 1
• Database Link:
  NP_066924
  Entrez Gene 12737 MouseEntrez Gene 65129 RatEntrez Gene 9076 Human
  UniProt ID O95832
• Background: claudin 1 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Belongs to the claudin family. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins.
• Synonyms: CLD1; ILVASC; SEMP1
• Note: Claudin 1 antibody detects endogenous levels of total Claudin 1

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Tight junction