NCoR (NCOR1) Rabbit Polyclonal Antibody

CAT#: TA347487

Rabbit Polyclonal Anti-NCoR1 Antibody

Product Images

Western blot analysis on MDA-MB-435 cell lysate using NCoR1 Antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-NCoR1 Antibody: A synthesized peptide derived from human NCoR1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 270 kDa
• Gene Name: nuclear receptor corepressor 1
• Database Link:
  NP_001177367
  Entrez Gene 20185 MouseEntrez Gene 9611 Human
  UniProt ID O75376
• Background: N-CoR1 is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9.
• Synonyms: hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1
• Note: NCoR1 antibody detects endogenous levels of total NCoR1

Reference Data

• Protein Families: Druggable Genome