DR4 (TNFRSF10A) Rabbit Polyclonal Antibody

CAT#: TA347514

Rabbit Polyclonal Anti-TR10A Antibody

Product Images

Western blot analysis on K562 cell lysate using TR10A Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TR10A Antibody: A synthesized peptide derived from human TR10A
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 50 kDa
• Gene Name: tumor necrosis factor receptor superfamily member 10a
• Database Link:
  NP_003835
  Entrez Gene 8797 Human
  UniProt ID O00220
• Background: TRAIL-R1 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
• Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
• Note: TR10A antibody detects endogenous levels of total TR10A

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity