MNK1 (MKNK1) Rabbit Polyclonal Antibody

CAT#: TA347568

Rabbit Polyclonal Anti-MKNK1 Antibody

Product Images

Western blot analysis on HeLa cell lysate using MKNK1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-MKNK1 Antibody: A synthesized peptide derived from human MKNK1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 51 kDa
• Gene Name: MAP kinase interacting serine/threonine kinase 1
• Database Link:
  NP_945324
  Entrez Gene 17346 MouseEntrez Gene 8569 Human
  UniProt ID Q9BUB5
• Background: Mnk1 a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described.
• Synonyms: MNK1
• Note: MKNK1 antibody detects endogenous levels of total MKNK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Insulin signaling pathway, MAPK signaling pathway