DMC1 Rabbit Polyclonal Antibody

CAT#: TA347571

Rabbit Polyclonal Anti-BARD1 Antibody

Product Images

Western blot analysis on HeLa cell lysate using BARD1 Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-BARD1 Antibody: A synthesized peptide derived from human BARD1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 86 kDa
• Gene Name: DNA meiotic recombinase 1
• Database Link:
  NP_008999
  Entrez Gene 11144 Human
  UniProt ID Q14565
• Background: BARD1 the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Colocalizes with BRCA1 into discrete subnuclear foci during S phase. Can translocate to the cytoplasm.
• Synonyms: dJ199H16.1; DMC1H; LIM15
• Note: BARD1 antibody detects endogenous levels of total BARD1

Reference Data

• Protein Families: Druggable Genome