FARP2 Rabbit Polyclonal Antibody

CAT#: TA347647

Rabbit Polyclonal Anti-FIR Antibody

Product Images

Western blot analysis on HuvEc cell lysate using FIR Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-FIR Antibody: A synthesized peptide derived from human FIR within aa 348-372.
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 119 kDa
• Gene Name: FERM, ARH/RhoGEF and pleckstrin domain protein 2
• Database Link:
  NP_055623
  Entrez Gene 227377 MouseEntrez Gene 9855 Human
  UniProt ID O94887
• Background: Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor.Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. 2 isoforms of the human protein are produced by alternative splicing.
• Synonyms: FIR; FRG; PLEKHC3
• Note: FIR Antibody detects endogenous levels of FIR

Reference Data

• Protein Pathways: Adherens junction