PINK1 Rabbit Polyclonal Antibody

CAT#: TA349062

Rabbit Polyclonal Anti-PINK1 Antibody


USD 484.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1 - 2 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification PINK1 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 55 kDa; Observed: 53 kDa
Gene Name PTEN induced putative kinase 1
Background The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).
Synonyms BRPK; PARK6
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Parkinson's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.