PINK1 Rabbit Polyclonal Antibody

CAT#: TA349069

Rabbit Polyclonal Anti-PDCL3 Antibody

Product Images

Western blot analysis of PDCL3 in human brain tissue lysate with PDCL3 antibody at 1 ug/mL.

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  Immunohistochemistry of PDCL3 in mouse lver tissue with PDCL3 antibody at 5 ug/mL.

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  Immunofluorescence of PDCL3 in mouse liver tissue with PDCL3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PDCL3 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human PDCL3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PDCL3 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 26 kDa; Observed: 25 kDa
• Gene Name: PTEN induced putative kinase 1
• Database Link:
  NP_115785
  Entrez Gene 68943 MouseEntrez Gene 298575 RatEntrez Gene 65018 Human
  UniProt ID Q9BXM7
• Background: Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2). PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3). Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding (4). Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling (5).
• Synonyms: BRPK; PARK6

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Parkinson's disease