ATG4A Rabbit Polyclonal Antibody

CAT#: TA349121

Rabbit Polyclonal Anti-NOSTRIN Antibody

Product Images

Western blot analysis of NOSTRIN in SW480 cell lysate with NOSTRIN antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of NOSTRIN in mouse kidney tissue with NOSTRIN antibody at 5 ug/mL.

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  Immunofluorescence of NOSTRIN in mouse kidney tissue with NOSTRIN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NOSTRIN antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NOSTRIN.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NOSTRIN antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 47, 53, 56, 62 kDa; Observed: 68 kDa
• Gene Name: autophagy related 4A cysteine peptidase
• Database Link:
  NP_840054
  Entrez Gene 666468 MouseEntrez Gene 678769 RatEntrez Gene 100910507 RatEntrez Gene 115201 Human
  UniProt ID Q8WYN0
• Background: NOSTRIN. also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins which may function as the modulator of the subcellular localisation and activity of endothelial nitric oxide synthase (eNOS) (1,2). It decreases NOS3 activity by inducing its translocation away from the plasma membrane (3). NOSTRIN typically exists as a trimer and is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. NOSTRIN is necessary for proper vascular development in zebrafish and postnatal retinal angiogenesis in mice (4,5).
• Synonyms: APG4A; AUTL2

Reference Data

• Protein Families: Protease
• Protein Pathways: Regulation of autophagy