WDR61 Rabbit Polyclonal Antibody

CAT#: TA349129

Rabbit Polyclonal Anti-WNT5 Antibody

Product Images

Western blot analysis of WNT5 in Jurkat cell lysate with WNT5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of WNT5 in rat colon tissue with WNT5 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: WNT5 antibody was raised against a 15 amino acid peptide near the center of human WNT5B.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: WNT5 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 39 kDa; Observed: 465 kDa
• Gene Name: WD repeat domain 61
• Database Link:
  NP_079510
  Entrez Gene 66317 MouseEntrez Gene 363064 RatEntrez Gene 80349 Human
  UniProt ID Q9GZS3
• Background: WNT5A and WNT5B are near-identical members of the WNT gene family, which consists of structurally related genes which encode secreted signaling proteins that have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis (1,2). WNT5A and WNT5B coordinate chondrocyte proliferation and differentiation by differentially regulating cyclin D1 and p130 expression, as well as chondrocyte-specific Col2a1 expression (3). Up-regulation of WNT5A and WNT5B has been observed in several types of human cancers, suggesting that they may be useful as diagnostic markers or potent therapeutic targets (4).
• Synonyms: REC14; SKI8

Reference Data

• Protein Pathways: RNA degradation