NOX3 Rabbit Polyclonal Antibody

CAT#: TA349147

Rabbit Polyclonal Anti-CRBN Antibody

Product Images

Western blot analysis of CRBN in human testis tissue lysate with CRBN antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of CRBN in rat testis tissue with CRBN antibody at 5 ug/mL.

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  Immunofluorescence of CRBN in rat testis tissue with CRBN antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CRBN antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 49 kDa; Observed: 54 kDa
• Gene Name: NADPH oxidase 3
• Database Link:
  NP_056533
  Entrez Gene 224480 MouseEntrez Gene 292279 RatEntrez Gene 50508 Human
  UniProt ID Q9HBY0
• Background: CRBN, a member of the Lon protease protein family, plays a role in brain development (1). It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8 (2). CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain (3,4).
• Synonyms: GP91-3; MOX-2

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Leukocyte transendothelial migration