LRRC8A Rabbit Polyclonal Antibody

CAT#: TA349193

Rabbit Polyclonal Anti-PMEPA1 Antibody

Product Images

Western blot analysis of PMEPA1 inA549 cell lysate with PMEPA1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PMEPA1 antibody was raised against a 16 amino acid peptide near the center of human PMEPA1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PMEPA1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 26, 28, 32 kDa; Observed: 27 kDa
• Gene Name: leucine-rich repeat containing 8 family member A
• Database Link:
  NP_062540
  Entrez Gene 241296 MouseEntrez Gene 311846 RatEntrez Gene 56262 Human
  UniProt ID Q8IWT6
• Background: The prostate transmembrane protein, androgen induced 1 (PMEPA1) protein is a transmembrane protein that contains a Smad interacting motif (SIM) (1,2). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins (3). Overexpression of this gene may play a role in multiple types of cancer (2,4).
• Synonyms: AGM5; LRRC8; SWELL1

Reference Data

• Protein Families: Transmembrane