DUSP10 Rabbit Polyclonal Antibody
Frequently bought together (2)
Other products for "DUSP10"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 200-1000 WB positive control: Mouse brain tissue IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Fusion protein of human DUSP10 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 53 kDa |
Gene Name | dual specificity phosphatase 10 |
Database Link | |
Background | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. |
Synonyms | MKP-5; MKP5 |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase |
Protein Pathways | MAPK signaling pathway |
Documents
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FAQs |
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