CCDC106 Rabbit Polyclonal Antibody

CAT#: TA349754

Rabbit Polyclonal Anti-CCDC106 Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 100-300
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human CCDC106
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: coiled-coil domain containing 106
• Database Link:
  NP_037433
  Entrez Gene 232821 MouseEntrez Gene 29903 Human
  UniProt ID Q9BWC9
• Background: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
• Synonyms: HSU79303; ZNF581