ROC2 (RNF7) Rabbit Polyclonal Antibody

CAT#: TA350357

Rabbit Polyclonal Anti-RNF7 Antibody

Product Images

Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane: Mouse liver tissue, Primary antibody: (RNF7 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes

• 

  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (RNF7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1000-2000, WB: 200-1000, IHC: 10-50
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human RNF7
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 13 kDa
• Gene Name: ring finger protein 7
• Database Link:
  NP_055060
  Entrez Gene 19823 MouseEntrez Gene 9616 Human
  UniProt ID Q9UBF6
• Background: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B).
• Synonyms: CKBBP1; ROC2; SAG

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Ubiquitin mediated proteolysis