RUNX2 Rabbit Polyclonal Antibody

CAT#: TA350633

Rabbit Polyclonal Anti-RUNX2 Antibody

Product Images

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (RUNX2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (RUNX2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: ELISA: 2000-5000, IHC: 25-100
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human RUNX2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: runt related transcription factor 2
• Database Link:
  NP_001019801
  Entrez Gene 12393 MouseEntrez Gene 860 Human
  UniProt ID Q13950
• Background: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
• Synonyms: AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA

Reference Data

• Protein Families: Druggable Genome, Transcription Factors